| 摘要 |
The (-) trans isomer of 4-(4'-fluorophenyl)-3-(3, 4'-methylenedioxyphenoxymethyl)-piperidine(paroxetine) according to formula (1) is used in therapy as the hydrochloride salt to treat inter alia depression, obsessive compulsive disorder (OCD) and panic. There is described a process for the preparation of a compound of formula (1) or a phramaceutically acceptable salt thereof, in which R<1> is a substituted phenyl group, the process comprising hydrolysing a solution of a carbamate of formula (2) in which R<1> is as defined above and R<2> is a C1-6 alkyl group, a C3-6 cycloalkyl group, aralkyl group, phenyl or substituted phenyl group; with a base by forming a finely divided complex derived from the base and the carbamate and heating it in suspension in a solvent.
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