CHIMERIC CHEMOKINE-ANTIGEN POLYPEPTIDES AND USES THEREFOR

摘要

The present invention provides chimeric polypeptides comprising: (a) one or more chemokine polypeptides selected from the group consisting of (i) chemokines and (ii) polypeptides within one or more of the following groups: fragments of chemokines, analogues of chemokines, derivatives of chemokines, and truncation isoforms of chemokines; (b) one or more antigenic polypeptides; and (c) one ore more polypeptide linkers connecting the one ore more chemokine polypeptides to the one or more antigenic polypeptide(s), and methods of making such chimeric polypeptides and methods of using such polypeptides for eliciting or enhancing an immune response.