发明名称 |
CARTILAGE RESORPTION ASSAYS |
摘要 |
Immunoassays for measuring type II collagen (cartilage) resorption <i>in vivo</i> employ either one or two antibodies. A first antibody binds to DEKAGGA (SEQ ID NO:21) but not to GGFDEKAGGAQLG (SEQ ID NO:27), where the K symbols refer to lysine or preferably to cross-linking 3-hydroxypyridinium residues. Measurement of analyte binding to the first antibody in serum provides an indication of unmineralized cartilage resorption <i>in vivo</i>. A second antibody binds to GGFDEKAGGAQLG but not to DEKAGGA. Measurement of analyte binding to the second antibody in serum provides an indication of mineralized cartilage resorption <i>in vivo</i>. An indication of total (unmineralized and mineralized) cartilage resorption <i>in vivo</i> is provided by either measurement of analyte binding to the first antibody in urine, or by measurement of the total analyte binding to the first and second antibodies in serum. |
申请公布号 |
WO0079284(A1) |
申请公布日期 |
2000.12.28 |
申请号 |
WO1999US29357 |
申请日期 |
1999.12.10 |
申请人 |
WASHINGTON RESEARCH FOUNDATION;EYRE, DAVID, R. |
发明人 |
EYRE, DAVID, R. |
分类号 |
G01N33/53;C07K7/04;C07K7/06;C07K7/08;C07K14/78;C07K16/18;G01N33/15;G01N33/50;G01N33/68;(IPC1-7):G01N33/68 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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