发明名称 |
Process for producing erythro-3-amino-2-hydroxybutyric acid derivatives |
摘要 |
<p>The present invention relates to a process for reacting alpha .aminoaldehyde derivatives having a sterically bulky amino group which are commercially available with a metal cyanide in the presence of an acid chloride, an acid anhydride or with an organic cyanide in the presence of a Lewis acid to synthesize 3-amino-2-hydroxybutyronitrile derivatives in high yields and high erythro selectivity. When optically active alpha .aminoaldehyde derivatives are used, racemization hardly occurs during the reaction, and the desired products are obtained in high optical purity.</p> |
申请公布号 |
EP1063232(A2) |
申请公布日期 |
2000.12.27 |
申请号 |
EP20000401792 |
申请日期 |
2000.06.22 |
申请人 |
DAISO CO., LTD. |
发明人 |
FURUKAWA, YOSHIRO;YAEGASHI, KEISUKE;HINOUE, KAZUMASA |
分类号 |
C07C227/02;C07C227/18;C07C227/32;C07C229/22;C07C229/34;C07C253/08;C07C255/43;C07C269/06;C07C271/22;C07D209/48;(IPC1-7):C07D209/48;C07C271/16 |
主分类号 |
C07C227/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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