Trypanosomatids histones for use as an antigen against trypanosomatic infection, including diagnostic tests, pharmaceutical compositions and vaccines of these antigens

摘要

Trypanosomatid histones in substantially isolated form are used as a protective antigen against trypanosomatic infection. These histones may be either isolated from the corresponding parasite (Leishmania) or be produced by means of recombinant DNA techniques. For the latter purpose genes encoding histones and derivatives of the genes like other nucleic acids and gene products like peptides and proteins are disclosed. Diagnostic tests, pharmaceutical compositions and vaccines comprising the usual excipients and/or adjuvants and at least one histone, a histone encoding gene or a derivative thereof are disclosed.