摘要 |
Method of preparing a compound of the general formula: Fac-[M(CO)3(OH2)3]+ wherein M is Mn, 99mTc, 186Re or 188Re, by reacting a metal in the permetallate form with carbon monoxide and a reducing agent, characterized in that a mixture of a base, a reducing agent soluble in water but not substantially decomposed by water, and optionally a stabilizing agent is solved in a water containing solvent system containing a solution of the metal in the permanganate, pertechnetate or perrhenate form in the presence of carbon monoxide and optionally in the presence of a halide. Also disclosed is a method of preparing a labelled compound with the aid of the compound of general formula I, a method of direct preparation of labeled compounds and a method of labeling of substrates such as amino acids, peptides, proteins, sugars, small receptor binding molecules and body cells with the aid of compound of general formal I. Disclosed is a kit for the preparation of a labelling composition and a kit for the preparation of a diagnostic of therapeutic pharmaceutical composition.
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