VACCINE FORMULATIONS AND METHODS FOR IMMUNIZING AN INDIVIDUAL AGAINST SHED ANTIGEN-SPECIFIC B CELLS

摘要

Provided are vaccine formulations for use in methods for inducing an immune response reactive with idiotypes on shed antigen-specific B cells in an individual, wherein administered to an individual is an immunologically effective amount of a vaccine formulation. Also provided are vaccine formulations comprising one or more peptides, wherein a peptide comprises an idiotype of an antibody that binds to an epitope of shed antigen; or one or more polynucleotides, wherein a polynucleotide encodes a peptide comprising an idiotype of an antibody that binds to an epitope of shed antigen.