| 发明名称 |
METHODS AND COMPOSITIONS FOR CONTROL OF BONE FORMATION VIA MODULATION OF LEPTIN ACTIVITY |
| 摘要 |
The invention relates to the method for treatment, diagnosis and prevention of bone disease and comprises methods including inhibiting or increasing leptin synthesis, leptin receptor synthesis, leptin binding to the leptin receptor, and leptin receptor activity. The invention also relates to screening assays to identify compounds that modulate leptin and/or leptin receptor activity. The invention further relates to gene therapy methods utilizing leptin and leptin-related sequences for the treatment and prevention of bone disease. |
| 申请公布号 |
WO0076552(A1) |
申请公布日期 |
2000.12.21 |
| 申请号 |
WO2000US15911 |
申请日期 |
2000.06.09 |
| 申请人 |
BAYLOR COLLEGE OF MEDICINE |
发明人 |
KARSENTY, GERARD;DUCY, PATRICIA;AMLING, MICHAEL |
| 分类号 |
G01N33/50;A61K31/21;A61K31/565;A61K31/711;A61K38/00;A61K38/17;A61K38/22;A61K38/43;A61K38/55;A61K38/57;A61K39/395;A61K45/00;A61K48/00;A61P19/08;A61P19/10;A61P43/00;C12Q1/02;G01N33/15;G01N33/566;G01N33/74;(IPC1-7):A61K48/00;C12Q1/68;C07H21/04;C07H21/02;G01N33/53 |
主分类号 |
G01N33/50 |
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