| 摘要 |
The present invention provides a composition comprising a semi-allogeneic hybrid fusion cell and an immunogenic peptide. In particular, isolated peptides of HIV (Human Immunodeficiency Virus), HTLV-1, Hepatitis B virus, Hepatitis C virus, rubeola virus, influenza A virus and Human Papilloma Virus are provided in the compositions of the present invention. Moreover, isolated cancer-specific peptides specific to a cancer, for example, B cell lymphoma, T cell lymphoma, myeloma, leukemia, breast cancer, pancreatic cancer, colon cancer, lung cancer, renal cancer, liver cancer, prostate cancer, melanoma and cervical cancer are provided in the compositions of the present invention. Moreover, the present invention provides a method of treating a subject infected by one or more of HIV, HTLV-1, Hepatitis B virus, Hepatitis C virus, rubeola virus, influenza A virus and Human Papilloma Virus, comprising administering a composition comprising an effective amount of a hybrid fusion cell and an effective amount of an isolated immunogenic peptide of the virus in a pharmaceutically acceptable carrier. Further, the present invention provides a method of treating cancer in a subject with one or more of B cell lymphoma, T cell lymphoma, myeloma, leukemia, breast cancer, pancreatic cancer, colon cancer, lung cancer, renal cancer, liver cancer, prostate cancer, melanoma and cervical cancer, comprising administering a composition comprising an effective amount of a hybrid fusion cell and an effective amount of an isolated immunogenic peptide of the cancer in a pharmaceutically acceptable carrier.
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| 申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;MEDICAL UNIVERSITY OF SOUTH CAROLINA;GATTONI-CELLI, SEBASTIANO;SHEARER, GENE;GRENE, EDITH;NEWTON, DANFORTH, A.;BROWN, EDWIN, A.;BERZOFSKY, JAY, A.;DEGROOT, ANNE, S. |
发明人 |
GATTONI-CELLI, SEBASTIANO;SHEARER, GENE;GRENE, EDITH;NEWTON, DANFORTH, A.;BROWN, EDWIN, A.;BERZOFSKY, JAY, A.;DEGROOT, ANNE, S. |
