Retro-inverso peptides derived from interleukin-6 (IL-6) having between 17 and about 40 amino acids and including the sequence shown in SEQ ID NO: 1. These peptides have the same activity as native IL-6 and also have neurotrophic activity. Because of the D-amino acid linkage in the peptides, they are less susceptible to proteolytic degradation <i>in vivo</i>.
申请公布号
WO0077033(A1)
申请公布日期
2000.12.21
申请号
WO2000US40227
申请日期
2000.06.16
申请人
MYELOS CORPORATION;WRIGHT, DAVID, E.;PARKS, D., ELLIOT