发明名称 |
NOVEL PYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT |
摘要 |
<p>This invention relates to pyridazine derivatives represented by the formula (1): <CHEM> wherein R<1> represents a lower alkoxyl group, a lower alkylthio group or a halogen atom; R<2> represents H, a lower alkoxyl group, a lower alkylthio group or a halogen atom; R<3> represents a lower alkyl or lower alkenyl group, which may be substituted by one or more OHs, CNs, lower cycloalkyl groups, (substituted) aromatic groups or (substituted) carbamoyl groups; R<4> represents COOH, a lower alkoxycarbonyl group, a (substituted) carbamoyl group, a (substituted) amino group, or a (substituted) ureido group; and the dashed line indicates that the carbon-carbon bond between the 4-position and the 5-position is a single bond or a double bond, or salts thereof; and also to medicines containing them as effective ingredients. These compounds have excellent inhibitory activity against interleukin-1 beta production, and are useful as preventives and therapeutics for immune system diseases, inflammatory diseases, ischemic diseases and the like.</p> |
申请公布号 |
EP1061077(A1) |
申请公布日期 |
2000.12.20 |
申请号 |
EP19990906509 |
申请日期 |
1999.02.26 |
申请人 |
KOWA CO., LTD. |
发明人 |
OHKUCHI, MASAO;KYOTANI, YOSHINORI;SHIGYO, HIROMICHI;YOSHIZAKI, HIDEO;KOSHI, TOMOYUKI;KITAMURA, TAKAHIRO;MATSUDA, TAKAYUKI;ODA, SOICHI;HABATA, YURIKO;KOTAKI, KYOKO |
分类号 |
A61P19/02;A61K31/50;A61K31/501;A61P19/10;A61P29/00;A61P37/00;C07D213/00;C07D237/00;C07D237/02;C07D237/04;C07D237/22;C07D237/24;C07D401/06;C07D401/12;(IPC1-7):C07D237/24 |
主分类号 |
A61P19/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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