发明名称 |
Processes for the production of HCMV glycoproteins, antibodies thereto and HCMV vaccines, and recombinant vectors therefor |
摘要 |
HCMV glycoproteins B and H have been identified. The gB protein is encoded by DNA in the HindIII F fragment of the HCMV genome lying between 1378 and 4095 bases from the F/D boundary. The gH protein is encoded by DNA in the HindIII L fragment lying between 228 and 2456 bases from the L/D boundary. The genes have been incorporated in recombinant vaccinia vectors and expressed in host animals to raise HCMV-neutralising antibody, thereby indicating vaccine potential. The glycoproteins can also be used in a variety of different ways, as vaccines or in the production, purification or detection of HCMV antibody.
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申请公布号 |
US6162620(A) |
申请公布日期 |
2000.12.19 |
申请号 |
US19940278048 |
申请日期 |
1994.07.20 |
申请人 |
COGENT LIMITED |
发明人 |
SMITH, GEOFFREY LILLEY;CRANAGE, MARTIN PATRICK;BARRELL, BARCLAY GEORGE |
分类号 |
A61K39/00;C07K14/045;C07K16/08;(IPC1-7):C12Q1/70;G01N33/53;A61K39/29 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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