发明名称 |
Process for the manufacture of bisphosphine oxide and bisphosphonate compounds |
摘要 |
A process for the manufacture of bisphosphine oxide compounds and bisphosphonates as intermediates for the production of bisphosphine ligands, in which in a single step process a) a phosphine oxide compound is reacted in an organic solvent at -70 DEG C. to 20 DEG C. with 0.5-3 eq. of a lithium or magnesium amide compound, b) 0.5-3 eq. of oxidatively-acting metal salt or metal salt complex are added to the suspension obtained in stage a) in a temperature range of -70 DEG C. to 20 DEG C., with a racemate of a bisphosphine oxide compound being obtained; c) a racemate cleavage is carried out if desired; and d) the bisphosphonates obtained in stage b) or c) are converted into bisphosphine oxides.
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申请公布号 |
US6162929(A) |
申请公布日期 |
2000.12.19 |
申请号 |
US19980212646 |
申请日期 |
1998.12.15 |
申请人 |
HOFFMANN-LA ROCHE INC. |
发明人 |
FORICHER, JOSEPH;SCHMID, RUDOLF |
分类号 |
B01J31/24;C07B37/04;C07B57/00;C07F9/40;C07F9/53;C07F9/655;C07F9/6553;(IPC1-7):C07D333/50 |
主分类号 |
B01J31/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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