A novel baculovirus/adenovirus hybrid vector for the rescue, production and titration of high-capacity adenovirus amplicon vectors

摘要

The present invention describes a recombinant baculovirus hybrid helper virus that is comprised of baculovirus sequences and second viral structural and late viral sequences. The invention also describes a method of producing gutless viral vectors that are substantially free from helper virus contamination. Furthermore, the invention describes a recombinant baculovirus BAC-B4 (VSVG).