Compositions and methods for the therapeutic use of an LTiGTatonalLT/iGT-associated sequence for deafness, osteoarthritis, and abnormal cell proliferation

摘要

Compositions and methods are disclosed for the therapeutic use of an atonal- associated nucleic acid or amino acid sequence. Also, an animal heterozygous for an atonal -associated gene inactivation is also disclosed having at least one atonal -associated nucleic acid sequence replaced by insertion of a heterologous nucleic acid sequence used to detect expression driven by an atonal -associated promoter sequence, wherein the inactivation of the atonal -associated nucleic acid sequence prevents expression of the atonal-associated nucleic acid.