ADENOVIRUS RECOMBINANTS CODANT POUR LE TRANSPORTEUR SPECIFIQUE DE L'IODE (NIS)

摘要

The invention concerns the field of gene therapy and the treatment of tumours. More particularly, the invention concerns the insertion of a gene coding for the iodine specific carrier (Na<+>/I<-> symporter) (NIS) in tumour cells using an adenoviral vector to promote the accumulation of iodine in said cells. The invention also concerns the defective recombinant adenoviruses for replication comprising the nis gene and the use of said vectors in a method for treating cancers combining nis gene transfer into tumour cells and metabolic radiotherapy.