发明名称 |
METHOD FOR IDENTIFYING COMPOUNDS WHICH AFFECT SYNAPTOGENESIS |
摘要 |
A method is provided for identifying a compound which affect the formation of AMPA receptors into aggregates. A method is also provided for identifying a compound which affects the formation of synaptic connections. A method is provided for identifying a compound that modulates immediate early gene expression. A method is further provided for increasing the number of excitory synapses of a neuron, including introducing into the neuron a polynucleotide sequence encoding a Narp operatively linked to a promoter, or a Narp polypeptide, thereby increasing the number of excitory synapses of the neuron. A method is provided for treating a subject with a disorder associated with a decrease in a function or expression of Narp, including administering to the subject a therapeutically effective amount of a compound that augments Narp function or expression. A method is provided for treating a subject with a disorder associated with an increase in a function or expression of Narp, including administering to the subject a therapeutically effective of a compound that inhibits Narp function or expression. A method is provided for treating a patient having or at risk of having a disorder associated with decreased Narp expression. The method includes introducing into a cell of a patient having a disorder associated with decreased Narp expression or function a polynucleotide sequence encoding a Narp polypeptide operatively linked to a promoter. A method is provided for treating a subject having a deficiency in a neuron's immediate early gene responsiveness to a stimulus. The method includes administering a nucleic acid encoding a Narp polypeptide to said subject, wherein the administration results in amelioration of the deficiency.
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申请公布号 |
WO0075661(A1) |
申请公布日期 |
2000.12.14 |
申请号 |
WO2000US15978 |
申请日期 |
2000.06.08 |
申请人 |
THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE |
发明人 |
WORLEY, PAUL;O'BRIEN, RICHARD;XU, DESHENG;HUGANIR, RICHARD, L. |
分类号 |
G01N33/94;(IPC1-7):G01N33/53;A01N43/04;A61K31/70;C07H21/04;C12P21/06;C12Q1/02 |
主分类号 |
G01N33/94 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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