APPARATUS AND METHOD FOR FLOW THROUGH CHEMISTRY

摘要

An apparatus (10) and method for chemical processing of multiple mixtures is disclosed. The apparatus (10) provides selective purging of a liquid-phase of the mixtures. The apparatus (10) can be used for processing many different types of mixtures under a wide variety of processing conditions, including but not limited to protein digestions, and is particularly suited for processes for containing the mixtures. The wells (16) have openings (18) that generally define a surface. A perforated plate (22) and a film (20) are disposed above the openings (18) of the wells (16). The film (20) is sandwiched between the perforated plate (22) and the surface defined by the openings (18) of the wells (16), covering and sealing the wells (16). A probe is used to perforate the film (20) and to pressurize the wells (16), which drives liquid out of the wells (16) via through-holes (32) formed in their bottoms (36).