EXCITATORY AMINO ACID RECEPTOR MODULATORS

摘要

Compounds of formula (I) in which R<1> is halo-C1-10 alkyl; halo-C2-10 alkenyl; or (CH2)nY in which n is 1 or 2 and Y is OH, CN, N3, OR<3>, SH, S(O)pR<4>, S(O)3H, NH2, NHR<5>, NR<6>R<7>, NHCOR<8>, NO2, CO2H, CONHR<9>, 1H-tetrazol-5-yl, 5-phenyltetrazol-2-yl, or PO3H2; R<3>, R<5>, R<6>, R<7>, R<8>and R<9> are each selected independently from C1-4 alkyl, aryl and aryl-C1-4 alkyl; R<4> is selected from C1-4 alkyl, aryl, aryl-C1-4 alkyl, 1H-tetrazol-5-yl, carboxy-(1-4C)alkyl and 1H-tetrazol-5-yl-C1-4 alkyl; and p is 0, 1, 2 or 3; or a salt or ester thereof, provided that R<1> is not methoxymethyl, modulate metabotropic glutamate receptor function and are useful in treating disorders of the central nervous system.