CATALYTIC ASYMMETRIC AMINOHYDROXYLATION WITH AMINO-SUBSTITUTED HETEROCYCLES

摘要

Amino-substituted heterocycles are disclosed to be suitable nitrogen sources for the osmium catalyzed asymmetric aminohydroxylation of olefins, achieving suprafacial, vicinal addition of a heterocycle moiety and a hydroxyl group. The enantioselectivities are strongly dependent on the nature of the heterocycles and are comparable to those of standard nitrogen sources. Instead of merely providing a route to protected aminoalcohols, the AA can now also be considered as a means to introduce complex substructures to hydrocarbon backbones.