| 摘要 |
The inventation describes the use of ouabain or an ouabain-like molecule for protection against apoptosis in various organs or tissues. The compound acts by inhibiting the Na+, k+ pump, thereby inverting the physiologically low intracellular Na+/k+ ratio required for progression of apoptosis (e.g. in VSMC). Therefore, the molecule can be used to treat disorders of diseases due to increased apoptosis, such as cardiopathies myocardial ischemia/angina, infarct or infection, congestive heart failure, cns or neurodegenerative disorders, trauma, reperfusion injury, severe burn or renal failure.
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