发明名称 |
SUBSTRATE TRAPPING PROTEIN TYROSINE PHOSPHATASES |
摘要 |
Compositions and methods are provided pertaining to novel substrate trapping mutant protein tyrosine phosphatases (PTPs) that are catalytically impaired but which retain the ability to bind phosphotyrosine-containing protein substrate(s), and that are further modified by the replacement of at least o ne tyrosine residue with an amino acid that cannot be phophorylated. Uses of su ch PTPs for identification of PTP substrates, and of agents that alter PTP- substrate interactions are disclosed, as are methods of altering PTP activities.
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申请公布号 |
CA2375145(A1) |
申请公布日期 |
2000.12.14 |
申请号 |
CA20002375145 |
申请日期 |
2000.05.24 |
申请人 |
COLD SPRING HARBOR LABORATORY |
发明人 |
TONKS, NICHOLAS K.;ZHANG, SHAO-HUI |
分类号 |
G01N33/50;A61K38/45;A61P35/00;A61P43/00;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/16;C12N15/09;C12Q1/42;G01N33/15;G01N33/566;(IPC1-7):C12N15/52;A61K38/00;C12N15/11;C12N15/62 |
主分类号 |
G01N33/50 |
代理机构 |
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主权项 |
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地址 |
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