METHODS AND COMPOSITIONS FOR PREVENTING p53 MEDIATED APOPTOSIS

摘要

Methods and compositions are provided for preventing p53 mediated apoptosis in host. In the subject methods, an effective amount of an agent having hAPP anti-p53 apoptotic activity is administered to the host. The subject methods find use in the treatment of disease conditions associated with p-53 mediated apoptosis, particularly p53 mediated neuronal apoptosis, e.g., neurodegenerative diseases such as Alzheimer's Disease.