NOVEL ISOQUINOLINE DERIVATIVES OR SALTS THEREOF

摘要

Novel isoquinoline derivatives represented by general formula (I) or salts thereof which have an If current inhibitory effect without any serious side effects such as convulsion; and drugs, in particular, cardiac rate lowering agents containing these compounds as the active ingredient. Namely, dialkoxy-1,2,3,4-tetrahydroquinoline-2-carbonylpiperidino-3,4-dialkoxypropananilide derivatives, etc. which have an If current inhibitory effect and are useful, as cardiac rate lowering agents, particularly in preventing ischemic heart diseases such as precordial anxiety (thoracic precordial anxiety) and myocardial infarct, and circulatory diseases such as congestive heart failure and arrhythmia (supraventricular arrhythmia, etc.).