The present invention relates to genetically modified CD34+ hematopoietic cells which overexpress a BCL-xL protein, cell populations comprising such cells and their medical uses. The present invention also relates to methods of enforced BCL-xL expression in hematopoietic cells. Such enforced expression results in an increase in hematopoietic cell viability, expansion, and engraftment ability.
申请公布号
WO0075291(A2)
申请公布日期
2000.12.14
申请号
WO2000EP05195
申请日期
2000.06.06
申请人
NOVARTIS AG;NOVARTIS-ERFINDUNGEN VERWALTUNGSGESELLSHAFT M.B.H.;SIRENKO, OKSANA, IVANIVNA;COOKE, MICHAEL, PAUL