PROCESS FOR THE PREPARATION OF SUPPORTS FOR SOLID PHASE SYNTHESIS
摘要
<p>A method for preparing a solid support material for carrying out a chemical reaction, said method comprising the following steps: (i) reacting an amino functionalised solid material with a carboxylic acid having at least two similarly protected amino groups to form amide bonds between them, (ii) removing protecting groups in a single step, (iii) optionally repeating steps (i) and (ii) one or more times using the product of the preceding step as the amino functionalised solid material, and (iv) connecting a linkage agent to at least some of the free NH2 groups of the product. The method increases the loading capacity of the solid support material. It is particularly useful in connection with peptide synthesis.</p>
申请公布号
WO0075171(A1)
申请公布日期
2000.12.14
申请号
WO2000GB02007
申请日期
2000.05.25
申请人
AVECIA LIMITED;BROWN, RICHARD, JOHN;MONTGOMERY, FRANCIS, JOSEPH;HARRIS, CRAIG, STEVEN;WELLINGS, DONALD, ALFRED
发明人
BROWN, RICHARD, JOHN;MONTGOMERY, FRANCIS, JOSEPH;HARRIS, CRAIG, STEVEN;WELLINGS, DONALD, ALFRED