发明名称 |
Methods and compositions for identifying receptor effectors |
摘要 |
The present invention makes available a rapid, effective assay for screening and identifying pharmaceutically effective compounds that specifically interact with and modulate the activity of a cellular protein, e.g., a receptor or ion channel. The subject assay enables rapid screening of large numbers of compounds to identify those which act as an agonist or antagonist to the bioactivity of the cellular protein. The subject assay is particularly amenable for identifying surrogate ligands for receptors especially from small molecule or peptide libraries or from peptides produced by an autocrine system.
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申请公布号 |
US6159705(A) |
申请公布日期 |
2000.12.12 |
申请号 |
US19970936632 |
申请日期 |
1997.09.24 |
申请人 |
CADUS PHARMACEUTICAL CORPORATION |
发明人 |
TRUEHEART, JOSHUA;PAUL, JEREMY I.;FUERNKRANZ, HANS A.;NATHAN, DEBRA;HOLMES, SCOTT |
分类号 |
C12N15/00;C07K14/39;C07K19/00;C12N1/16;C12N1/19;C12N15/09;C12N15/81;C12Q1/00;C12Q1/02;C12Q1/37;C12Q1/42;C12Q1/48;C12Q1/68;(IPC1-7):C12N1/19 |
主分类号 |
C12N15/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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