发明名称 |
Site specific binding system, nuclear imaging compositions and methods |
摘要 |
A method for ligand-based binding of lipid encapsulated particles to molecul ar epitopes on a surface in vivoor in vitrocomprises sequentially administering (a) a site-specific ligand activated with a biotin activating agent; (b) an avidin activating agent; and (c) lipid encapsulated particles activated with a biotin activating agent, whereby the ligand is conjugated t o the particles through an avidin-biotin interaction and the resulting conjuga te is bound to the molecular epitopes on such surface. The conjugate is effecti ve for imaging by x-ray, ultrasound, magnetic resonance, positron emission tomography or nuclear imaging. Compositions for use in ultrasonic imaging of nature or synthetic surfaces and for enhancing the acoustic reflectivity thereof are also disclosed. |
申请公布号 |
AU4097599(A) |
申请公布日期 |
2000.12.12 |
申请号 |
AU19990040975 |
申请日期 |
1999.05.25 |
申请人 |
BARNES-JEWISH HOSPITAL |
发明人 |
GREGORY M. LANZA;SAMUEL A. WICKLINE |
分类号 |
G01R33/28;A61B5/055;A61B8/06;A61K9/107;A61K9/127;A61K49/00;A61K49/04;A61K49/18;A61K51/00;A61K51/10;A61K51/12;C07F5/00;G01N33/483;G01N33/566;G01N33/577;G01N33/58 |
主分类号 |
G01R33/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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