发明名称 |
Oligonucleotide-anthracycline and oligonucleotide-anthracyclinone conjugates |
摘要 |
PCT No. PCT/EP97/01246 Sec. 371 Date Sep. 9, 1998 Sec. 102(e) Date Sep. 9, 1998 PCT Filed Mar. 12, 1997 PCT Pub. No. WO97/33897 PCT Pub. Date Sep. 18, 1997The present invention refers to conjugates formed by a natural or modified oligonucleotide, capable of forming a triple helix with a DNA chain, linked to the aglycone moiety of an anthracycline or to an anthracyclinone via an appropriated linker; such conjugates are capable to bind selectively to specific DNA regions inhibiting their transcription and therefore the formation of the corresponding codified protein.
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申请公布号 |
US6160102(A) |
申请公布日期 |
2000.12.12 |
申请号 |
US19980142521 |
申请日期 |
1998.09.09 |
申请人 |
CONSIGLIO NAZIONALE DELLE RICERCHE |
发明人 |
GARBESI, ANNA MARIA;BONAZZI, STEFANIA;ZANELLA, STEFANIA;CAPOBIANCO, MASSIMO LUIGI;GIANNINI, GIUSEPPE;ARCAMONE, FEDERICO |
分类号 |
C07H17/04;C07H21/00;(IPC1-7):C12Q1/68;C07H19/00;C07H21/02;C07H21/04;C07H15/24 |
主分类号 |
C07H17/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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