发明名称 |
T-BET COMPOSITIONS AND METHODS OF USE THEREOF |
摘要 |
Isolated nucleic acid molecules encoding T-bet, and isolated T-bet proteins, are provided. The invention further provides antisense nucleic acid molecule s, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals carrying a T-bet transgene. The invention further provides T-bet fusion proteins and anti-T-bet antibodies. Methods of using the T-bet compositions of the invention are also disclosed, including methods for detecting T-bet activity in a biological sample, methods of modulating T-bet activity in a cell, and methods for identifying agents that modulate the activity of T-bet.
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申请公布号 |
CA2375050(A1) |
申请公布日期 |
2000.12.07 |
申请号 |
CA20002375050 |
申请日期 |
2000.06.01 |
申请人 |
PRESIDENT AND FELLOWS OF HARVARD COLLEGE |
发明人 |
GLIMCHER, LAURIE H.;SZABO, SUSANNE J. |
分类号 |
A01K67/027;A61K38/00;C07K14/47;C07K16/18;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12N15/12;C12P21/02;C12Q1/68;G01N33/15;G01N33/50;G01N33/53;(IPC1-7):C12N15/12;A61K38/17 |
主分类号 |
A01K67/027 |
代理机构 |
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主权项 |
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