| 摘要 |
The invention provides human and murine isolated nucleic acid molecules, designated A259 nucleic acid molecules, which encode secreted proteins with homology to integrin alpha subunits, specifically to integrin alpha 10. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
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