发明名称 |
C-CAM AS AN ANGIOGENESIS INHIBITOR |
摘要 |
The present invention relates generally to the fields hyperproliferative disease and angiogenesis. More particularly, the present invention demonstrates that a C-CAM1 cytoplasmic domain is necessary and sufficient for inhibiting angiogenesis. In particular embodiments, it relates to inhibiting hyperproliferative cell growth by administering to a cell a C-CAM1 cytoplasmic domain or an expression construct encoding a C-CAM1 cytoplasmic domain. In other embodiments, angiogenesis is inhibited by administering to a subject a C-CAM1 polypeptide or an expression construct encoding a C-CAM1 polypeptide. |
申请公布号 |
WO0073340(A1) |
申请公布日期 |
2000.12.07 |
申请号 |
WO2000US14597 |
申请日期 |
2000.05.26 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
LIN, SUE-HWA;LUO, WEIPING;LOGOTHETIS, CHRISTOPHER |
分类号 |
C12N15/09;A61K35/76;A61K38/00;A61K48/00;A61P35/00;A61P43/00;C07K14/705 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|