| 发明名称 |
ALPHA V INTEGRIN RECEPTOR ANTAGONISTS |
| 摘要 |
The present invention relates to novel nonanoic acid derivatives, their synthesis, and their use as alphaV integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors alphaV beta3 and alphaV beta5 and are useful for inhibiti ng bone resorption, treating and preventing osteoporosis, and inhibiting vascul ar restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, inflammatory arthritis, viral disease, cancer , and metastatic tumor growth.
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| 申请公布号 |
CA2373937(A1) |
申请公布日期 |
2000.12.07 |
| 申请号 |
CA20002373937 |
申请日期 |
2000.05.30 |
| 申请人 |
MERCK & CO., INC. |
发明人 |
MEISSNER, ROBERT S.;HUTCHINSON, JOHN H.;PATANE, MICHAEL A.;PERKINS, JAMES J.;COLEMAN, PAUL J.;HARTMAN, GEORGE D.;WANG, JIABING;HALCZENKO, WASYL;DUGGAN, MARK E.;BRESLIN, MICHAEL J. |
| 分类号 |
A61K31/437;A61K31/4375;A61K31/4709;A61K31/498;A61K31/501;A61K31/505;A61K31/506;A61K31/536;A61K31/55;A61P9/00;A61P9/08;A61P9/10;A61P17/00;A61P19/08;A61P19/10;A61P27/02;A61P29/00;A61P31/12;A61P35/00;A61P35/04;A61P43/00;C07D213/02;C07D221/00;C07D223/14;C07D239/24;C07D239/48;C07D241/36;C07D265/28;C07D401/06;C07D471/02;C07D471/04;C07D519/00;(IPC1-7):C07D487/12;C07D401/04;C07D409/06;C07D401/14;C07D409/14;C07D413/14;C07D417/14;A61K31/442;A61K31/535;A61K31/541 |
主分类号 |
A61K31/437 |
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