| 摘要 |
<p>The present invention provides a method of enhancing immunity in a mammal. The method comprises modifying a dendritic cell (DC) in vivo or ex vivo to produce a dendritic cell-mediator in the mammal. The dendritic cell-mediator up-regulates DC in the mammal, thereby enhancing immunity in the mammal. The present invention further provides a method of inducing an immune response to an antigen, cancer, or infectious disease in a mammal. In one embodiment, the method comprises administering the antigen or an antigen of the cancer or infectious disease to a mammal, which has been treated as described above, whereupon an immune response to the antigen, cancer, or infectious disease, respectively, is induced in the mammal. In another embodiment, the method comprises administering a DC to a mammal as described above, however, the method further comprises contacting the DC, which has been modified to produce a dendritic cell-mediator, with the antigen or an antigen of the cancer or infectious disease prior to administration of the DC to the mammal, whereupon an immune response to the antigen, cancer or infectious disease, respectively, is induced in the mammal.</p> |
