POLYMORPHS OF A CRYSTALLINE AZABICYCLO (2,2,2) OCTAN-3-AMINECITRATE AND THEIR PHARMACEUTICAL COMPOSITIONS

摘要

A single crystalline polymorphic form (2S, 3S)-N-(methoxy-5-t- butylphenylmethyl-2-diphenylmethyl-1-azobicyclo (2,2,2) octan-3-amine citrate(citrate monohydrate) and its pharmaceutical composition. The pharmaceutical composition of the polymorphic form if the citrate monohydrat e has advantageous stability for formulation to treat emesis. The administrati on of this pharmaceutical composition is immediate release, oral dosage form preferably by tablet or capsule or intravenous.