发明名称 |
Arylpiperazinylalkyl-3(2H)-pyridazinones as serotonin 5HT and dopamine D2 receptor agonists |
摘要 |
A description is given of new arylpiperazinylalkyl-3(2H)-pyridazinones of general formula (I) and their preparation and their addition salts with pharmaceutically acceptable acids, <CHEM> in which R1 is a methyl or phenyl radical, R2 is a hydrogen atom or a methyl radical, n takes values between 2 and 4, and R3 is a naphthyl radical or a phenyl radical, which are substituted by a radical such as methoxyl, trifluoromethyl and chlorine. The compounds present affinity for serotonin 5HT1A and 5HT2 receptors and for dopamine D2 receptors, and can be useful as antipsychotics. |
申请公布号 |
EP1057820(A1) |
申请公布日期 |
2000.12.06 |
申请号 |
EP20000500113 |
申请日期 |
2000.06.02 |
申请人 |
FAES, FABRICA ESPANOLA DE PRODUCTOS QUIMICOS Y FARMACEUTICOS, S.A. |
发明人 |
ORJALES VENERO, AURELIO;GARCIA-DOMINGUEZ, NEFTALI |
分类号 |
C07D401/06;A61K31/501;A61P25/18;A61P43/00;C07D237/14 |
主分类号 |
C07D401/06 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|