发明名称 |
SOLID SUPPORT SYNTHESIS OF 2-OXOPIPERAZINES |
摘要 |
<p>The subject invention involves processes for making 2-oxopiperazine and homologous compounds using a solid support resin by (a) removing the protecting group from an N-protected amino acid ester of the resin (if present), (b) reacting the resulting unprotected resin ester with a N-protected alpha -amino aldehyde, (c) optionally modifying the resulting intermediate by substituting a non-hydrogen moiety on the N from the amino acid, (d) removing the remaining N-protecting group from the N from the amino aldehyde, and (e) cleaving/cyclizing the product from the resin.</p> |
申请公布号 |
EP1056727(A1) |
申请公布日期 |
2000.12.06 |
申请号 |
EP19990905883 |
申请日期 |
1999.02.08 |
申请人 |
THE PROCTER & GAMBLE COMPANY |
发明人 |
GOLEBIOWSKI, ADAM;KLOPFENSTEIN, SEAN, REES |
分类号 |
C07D241/08;C07D243/08;C07D245/02;(IPC1-7):C07D241/08 |
主分类号 |
C07D241/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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