发明名称 |
METHODS FOR PREDICTING PREGNANCY OUTCOME IN A SUBJECT BY hCG ASSAY |
摘要 |
A method for predicting pregnancy outcome in a subject by determing the amount of EPMI-hCG in a sample from the subject using B152 antibody produced by the hybridoma cell line deposited with the American Type Culture Collection under Designation No. HB-12467; and a second, labelled antibody which binds to the complex formed by B152 antibody and EPMI-hCG to determine the amount of EPMI-hCG in the sample; using a third antibody which binds to intact, non-nicked hCG; and a fourth, labelled antibody which binds to intact non-nicked hCG simultaneously with the third antibody to determine the amount of intact hCG in the sample; and comparing the amount of EPMI-hCG in the sample with either the amount of EPMI-hCG determined in a sample from a temporally matched, normal pregnant subject or a non-pregnant subject, wherein an amount of EPMI-hCG in the subject's sample similar to the amount of EPMI-hCG in the sample from the temporally matched, normal pregnant subject or non-pregnant subject respectively indicates a positive or negative outcome of the pregnancy. |
申请公布号 |
EP1057000(A2) |
申请公布日期 |
2000.12.06 |
申请号 |
EP19990925541 |
申请日期 |
1999.02.03 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK |
发明人 |
O'CONNOR, JOHN F.;KOVALEVSKAYA, GALINA I.;BIRKEN, STEVEN |
分类号 |
G01N33/53;C12N15/02;G01N33/577;G01N33/76 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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