TETRAHYDROBENZINDOLE DERIVATIVES

摘要

This invention creates compounds represented by the following formula (1) which, alone or as a plurality of them simultaneously, act upon serotonin receptors, and thereby provides pharmaceutical compositions that contain these compounds and are useful for the treatment or prevention of diseases which are considered to be induced by the abnormality of central and peripheral serotonin controlling functions. <CHEM> In the formula, R<1> is a hydrogen atom, a lower alkyl group or an aralkyl group; R<2> is a hydrogen atom or a specified substituent; n is an integer of 2 to 6; and alpha is the following formula (a), (b), (c), (d) or (e). <CHEM> In formulae (a) and (b), R<3> is a hydrogen atom or a specified substituent; X is NR<10>, NCONR<11>R<12>, S, SO, SO2 or O; R<10> is a hydrogen atom or a specified substituent; R<11> and R<12> is independently a hydrogen atom or a lower alkyl; Y is a methylene group or a carbonyl group. In formula (c), R<4> is a hydrogen atom or a specified substituent; R<5> is a hydrogen atom or a specified substituent; k is 0 or an integer of 1 to 3; m is 0 or an integer of 1 to 3; each of A and B is a group which forms a specified ring via a double bond; k + m is an integer of 1 to 3. In formulae (d) and (e), R<4> is as defined above; G is CH2, S, O or C=O; D is CH or N; p is an integer of 1 to 3; each of E and J is a group which forms a benzene ring or a pyridine ring via a double bond; R<6> and R<7> is independently a hydrogen atom or a lower alkyl or the like specified substituent.