MICRODISPERSIONES DE FASE CONTINUA DE COMPUESTOS FLUORADOS PARA LA ADMINISTRACION DE AGENTES FARMACEUTICOS.
摘要
A method for preparing a pharmaceutical microdispersion exhibiting enhanced bioavailability, including the steps of providing a thermodynamically stable pharmaceutical composition comprising at least one lipophilic pharmaceutical agent incorporated in a physiologically acceptable liquid carrier, the liquid carrier comprising one or more lipophilic solvents such as fluorochemicals and preferably at least one nonfluorinated co-solvent, and combining the stable pharmaceutical composition with an amount of at least one miscible diluent sufficient to initiate phase separation of the lipophilic pharmaceutical agent from the pharmaceutical composition wherein a microdispersion of the pharmaceutical composition is formed. Also disclosed are microdisperse pharmaceutical compositions and kits for forming such compositions.
申请公布号
ES2150674(T3)
申请公布日期
2000.12.01
申请号
ES19960918172T
申请日期
1996.06.05
申请人
ALLIANCE PHARMACEUTICAL CORP.
发明人
TREVINO, LEO A.;DELLAMARY, LUIS, A.;TARARA, THOMAS, E.;WEERS, JEFFRY, G.;RANNEY, HELEN, M.