摘要 |
<p>Compounds of formula (I) in which R1 is an optionally substituted aryl or an optionally substituted heteroaryl ring; (R2)m is hydrogen or selected substituents; X is CH2 or CHR3 in which R3 is C¿(1-6)? alkyl or is linked to the orthoposition of an aryl or heteroaryl ring of R?1¿ to form a 5 to 7 membered ring optionally including oxygen or nitrogen as a ring atom; Y is C¿(1-3)? alkylene or C(4-6) cycloalkylene; are inhibitors of the bacterial enzyme S aureus methionyl t-RNA synthetase and are of use in treating bacterial infections.</p> |