IDENTIFICATION OF BROADLY REACTIVE HLA RESTRICTED T CELL EPITOPES

摘要

This application discloses five new amino acid supermotifs and corresponding grouping of HLA molecules (i.e., HLA supertypes that bind peptides that bear these supermotifs). Peptides epitopes bearing these supermotifs are selected for use in vaccines and other pharmaceutical compositions. The new supermotifs are used to screen known disease-related targets, as well as targets that will be determined in the future.