A multiparticulate controlled release selective serotonin reuptake inhibitor (SSRI) formulation for oral administration comprises particles of said SSRI or a phamaceutically acceptable salt thereof coated with rate-controlling polymer which allows controlled release of said SSRI, over a period of not less than about 12 hours following oral administration. The formulation, which contains for example fluvoxamine or a pharmaceutically acceptable salt thereof, is suitable for once or twice daily administration. The formulation can comprise a blend of two or more populations of particles, pellets or mini-tablets having different in vitro and/or in vivo release characteristics.
申请公布号
WO0071099(A1)
申请公布日期
2000.11.30
申请号
WO2000IE00060
申请日期
2000.05.10
申请人
ELAN CORPORATION, PLC;JEARY, THERESA, ANN;MORRISSEY, CATHERINE, ANN;STARK, PAUL
发明人
JEARY, THERESA, ANN;MORRISSEY, CATHERINE, ANN;STARK, PAUL