摘要 |
The present invention relates to optically active quinoline carboxylic acid derivatives, pharmaceutically acceptable salts thereof, solvates thereof, and a process for preparation thereof. More particularly, the present invention relates to optically active quinoline carboxylic acid derivatives having 4-aminomethyl-4-methyl-3-(Z)-alkoxyiminopyrrolidine substitutes causing optical activity at 7-position of quinolone. As the compounds of the present invention have superior antibacterial activity to enantiomers thereof, racemic mixtures thereof and other antibacterial agents, have a good pharmacokinetic characteristic and show no phototoxicity, the compound of this invention is useful for an antibacterial agent. |
申请人 |
DONG WHA PHARM. IND. CO., LTD.;YOON, SUNG, JUNE;CHUNG, YONG, HO;LEE, CHI, WOO;LEE, JIN, SOO;KIM, NAM, DOO;JIN, YOON, HO;SONG, WAN, JIN;KIM, IK, HOE;YANG, WANG, YONG;CHOI, DONG, RACK;SHIN, JUNG, HAN |
发明人 |
YOON, SUNG, JUNE;CHUNG, YONG, HO;LEE, CHI, WOO;LEE, JIN, SOO;KIM, NAM, DOO;JIN, YOON, HO;SONG, WAN, JIN;KIM, IK, HOE;YANG, WANG, YONG;CHOI, DONG, RACK;SHIN, JUNG, HAN |