<p>Stable alpha -substituted boronic esters, e.g. for use in peptide synthesis, are prepared by reacting a substituted alkene of the formula: <CHEM> with a disubstituted borane of the formula: <CHEM> wherein: (i) R<1> and R<2> are each selected from various groups which are preferably not leaving groups; (ii) X is halogen or other leaving group; (iii) Y is H or lower alkyl; (iv) Q<1> and Q<2> are each selected from various groups which are preferably such that the borane is non-hydrolyzable, and particularly Q<1> and Q<2> together may represent a residue of a diol such as catechol or pinanediol.</p>
申请公布号
GR3033965(T3)
申请公布日期
2000.11.30
申请号
GR20000401650T
申请日期
2000.07.17
申请人
THROMBOSIS RESEARCH INSTITUTE
发明人
ELGENDY, SAID MOHAMED ANWAR;DEADMAN, JOHN JOSEPH;PATEL, GEETA;GREEN, DONOVAN ST. CLAIRE;BABAN, JEHAN ANWAR;KAKKAR, VIJAY VIR;CLAESON, GORAN KARL