INDUCIBLE PACKAGING CELL LINES FOR LENTIVIRUS VECTORS
摘要
Novel packaging cell lines for production of lentiviral vectors are disclosed. The cell lines utilize an ecdysone-inducible system for virus production, thereby avoiding the cytotoxic effect of unregulated expression of certain envelope proteins and lentiviral proteins. Various embodiments of the cell lines are disclosed, which are suitable for different purposes that range from in vitro screening assays to gene therapy in vivo.
申请公布号
WO0071678(A1)
申请公布日期
2000.11.30
申请号
WO2000US14448
申请日期
2000.05.25
申请人
UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY;DOUGHERTY, JOSEPH, P.;ADELSON, MARTIN, E.;KAUL, MALVIKA;PACCHIA, ANNMARIE, L.;RON, YACOV