| 摘要 |
A hemostatic device for sealing blood vessels, particularly for use in angioplasty comprises: (1) a barrel including: (a) a cylindrical portion; and (b) a terminal tapered portion, the terminal tapered portion being divided by at least one slot cut therein so that the tapered portion expands radially when force is applied to it; and (iii) an aperture at the narrow end of the terminal tapered portion; (b) a proteinaceous powder in the cylindrical portion of the barrel, the proteinaceous powder including at least one protein that promotes hemostasis in a blood vessel, the aperture in the terminal tapered portion being for flow of the proteinaceous powder; and (c) a plunger inserted into the barrel, the plunger including: (i) a narrow portion including therein means for guiding a guidewire; and (ii) a conical portion extending from the narrow portion so that, when the plunger is inserted into the barrel, the large end of the conical portion is located closest to the tapered portion of the barrel. The proteinaceous powder can be fibrin, thrombin, or fibrinogen. In use, the device is inserted into the tissue in the vicinity of an artery during the performance of angioplasty over a guidewire and leaves a plug in the tissue to seal the artery.
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