CRYSTAL STRUCTURE DATA OF CYSTEINPROTEASE GINGIPAIN R

摘要

The objects of the present invention are a crystal structure of gingipain R as shown in (Fig. 1) and a crystal structure of a gingipain R in complex with H-D-Phe-Phe-Arg-chloromethylketone as shown in (Fig. 4). A further object is the use of such crystal structure to obtain crystal structure data for the design and/or identification of inhibitors of gingipain R, which again form part of the present invention, as well as pharmaceutical compositions containing such inhibitors.