发明名称 |
METHODS AND COMPOUNDS FOR INHIBITING AMYLOID DEPOSITS |
摘要 |
Methods and compositions which are useful in the treatment of amyloidosis. I n particular, methods and compositions are provided for inhibiting, preventing and treating amyloid deposition, e.g., in pancreatic islets, wherein the amyloidotic deposits are islet amyloid polypeptide (IAPP)-associated amyloid deposition or deposits. The methods of the invention involve administering t o a subject a therapeutic compound which inhibits IAPP-associated amyloid deposits. Accordingly, the compositions and methods of the invention are useful for inhibiting IAPP-associated amyloidosis in disorders in which such amyloid deposition occurs, such as diabetes.
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申请公布号 |
CA2373093(A1) |
申请公布日期 |
2000.11.30 |
申请号 |
CA20002373093 |
申请日期 |
2000.05.24 |
申请人 |
NEUROCHEM, INC.;QUEEN'S UNIVERSITY AT KINGSTON |
发明人 |
MIGNEAULT, DAVID;KONG, XIANQI;SZAREK, WALTER A.;WEAVER, DONALD E.;GUPTA, AJAY |
分类号 |
A61K45/00;A61K31/00;A61K31/185;A61K31/192;A61K31/194;A61K31/198;A61K31/205;A61K31/4015;A61K31/403;A61K31/4035;A61K31/4152;A61K31/428;A61K31/437;A61K31/44;A61K31/4409;A61K31/4418;A61K31/4439;A61K31/445;A61K31/4453;A61K31/465;A61K31/47;A61K31/4709;A61K31/472;A61K31/4725;A61K31/473;A61K31/4741;A61K31/675;A61K31/706;A61P1/18;A61P3/10;(IPC1-7):A61K31/00;A61P43/00;A61K31/470;A61K31/474 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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