A PROCESS FOR THE PREPARATION OF .BETA.-LACTAM DERIVATIVES

摘要

A process for the preparation of Cefuroxime acid (I), which comprises the following steps: (1) Extraction of deacetyl 7-glutaryl ACA (II) aqueous solution at acid pH with organic solvents (for example according to the procedures disclosed in US 5,801,241); (2) drying the resulting solution whi le preventing lactonization of the intermediate; (3) carbamoylation of the hydroxymethyl group at the 3- position by reaction with chlorosulfonyl isocyanate or similar products; (7) extraction of the carbamoyl derivative from step 3 with water at neutral pH; (8) enzymatic hydrolysis of the amide at the 7- position of the cephalosporanic ring with glutaryl acylase; (6) acylation of the amino group by condensation with 2-furanyl(sin- methoxyimino)acetic acid chloride or mixed anhydride.